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For example, melatonin has been found to stimulate the -secretase cleavage of APP in cultured neuronal and non-neuronal cells [52] via upregulation of the nonamyloidogenic ADAM10 and ADAM17 proteases
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Importantly, this relationship is relevant to humans as individuals with exceptional longevity are enriched with functional IGF-1R mutations 13 , while low IGF-1 levels predict better survival in female nonagenarians 16
10.1038/sj.ejcn.1601768
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doi: 10.1186/s12943-020-01238-x
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